It is the year 2201. The Yamato has returned from the devastating battle with Emperor Zordar and the Comet Empire. Sanada, Aihara, and Shima are released from the hospital, and go to pay their respects to the fallen crew members at Okita's memorial. They meet Tokugawa's son Tasuke, who says that he will be joining the crew once he graduates from cadet school. The next day at his graduation, he ends up capsizing a boat full of new cadets because they are all too busy staring at the Yamato to watch where they are going. After some problems during launch due to the new engine crew hitting the wrong switches and stalling the ship, the Yamato departs on what should be a simple training mission. (Source: AniDB)

In the year 2199, Earth is a mere shell of its former glory after a vicious bombardment by the Gamilas Empire. The inhabitants have been forced underground to escape the irradiated surface, but the deadly radiation inches closer and closer to the retreating population. With only one year before complete and utter extermination, time is fast running out and hope is in short supply. So far, any attempt to escape or retaliate has been instantly annihilated by the alien empire—until an emergency transmission from the planet Iscandar in a neighboring galaxy offers a glimmer of hope to save the doomed planet. Covertly, Earth's Self Defense Force constructs a faster than light engine for a journey to Iscandar. Armed with new weapons and a determined crew of fearless navy men, the World War II era battleship Yamato is reborn as Space Battleship Yamato. She and her crew set out on a perilous journey across the stars to save their home and the entire human race.

A year has passed since the Star Force returned to save the Earth but another danger now approaches from deep space. A gigantic White Comet hurtles toward our galaxy, obliterating everything in its path. But it is no ordinary comet—it is the deadly Comet Empire, conqueror of worlds... and Earth is the next target! Against orders, the Star Force blasts off to investigate, but even if they can get past the flagship Andromeda, they don't yet know the true nature of their new enemy! (Source: AniDB)