To the average person, psychic abilities might seem a blessing; for Kusuo Saiki, however, this could not be further from the truth. Gifted with a wide assortment of supernatural abilities ranging from telepathy to x-ray vision, he finds this so-called blessing to be nothing but a curse. As all the inconveniences his powers cause constantly pile up, all Kusuo aims for is an ordinary, hassle-free life—a life where ignorance is bliss. Unfortunately, the life of a psychic is far from quiet. Though Kusuo tries to stay out of the spotlight by keeping his powers a secret from his classmates, he ends up inadvertently attracting the attention of many odd characters, such as the empty-headed Riki Nendou and the delusional Shun Kaidou. Forced to deal with the craziness of the people around him, Kusuo comes to learn that the ordinary life he has been striving for is a lot more difficult to achieve than expected.

The disastrous life of the gifted psychic Kusuo Saiki continues, despite his utmost effort to live an ordinary life. Although he has certainly grown accustomed to dealing with his troublesome friends—who are his biggest hurdle to achieving a peaceful life—he still has a long way to go. Also joining the usual oddballs are a few new faces whose shenanigans add to Saiki's misery, making his dreams of a hassle-free life a distant fantasy.