The demon Jashin-chan has been summoned to Earth by Yurine Hanazono, a girl with a knack for the occult. Unfortunately, Yurine does not actually know how to send Jashin-chan back to Hell. Now stuck on Earth, she must live at Yurine's apartment as her familiar. The only way for Jashin-chan to return would be to kill her summoner, but this is easier said than done for the incompetent demon. Since Jashin-chan is immortal and can regenerate her body, Yurine does not hold back in attacking her with a range of weapons, punishing her in gruesome manners for her evil schemes. Jashin-chan is also often visited by her demon friends: the kindhearted Gorgon Medusa and the energetic minotaur Minosu, who seem much more well-behaved in contrast, and disapprove of her plans to kill Yurine. Jashin-chan Dropkick is a comedy focusing on these two reluctant roommates and their bizarre antics as they get by with their cat-and-mouse relationship.

Jashin-chan is a demon who was summoned by Yurine Hanazono, a gothic looking girl. Unable to return home as the relevant spell was not included in the summoning grimoire, Jashin-chan resorts to violence to liberate herself from her earthly shackles. However, this is easier said than done, as Yurine is no weakling herself. She in fact possesses formidable physical power and uses it to massacre Jashin-chan in a variety of ways, be it shoving her arm in a blender, spreading her intestines across the room or even cooking her. Though these actions would be fatal to anyone without the ability to regenerate, Jashin-chan isn't exactly undeserving of this treatment. Stuck with each other, Yurine lets Jashin-chan live with her in exchange for work around the apartment, and this cohabitation results in situations where, more often than not, Jashin-chan ends up in pieces.

Many of us know what it is like to transition to a new school with few to no friends in a new environment, going through the arduous process of getting to know people again. Bocchi Hitori knows this struggle all too well, having just graduated from elementary school and thrown into middle school. Unfortunately, she suffers from extreme social anxiety: she faints when overwhelmed, vomits when nervous, and draws up ridiculously convoluted plans to avoid social contact. It does not help that her only friend from elementary school, Kai Yawara, will not be attending the same middle school as Bocchi. However, wanting to help her, Kai severs ties with Bocchi and promises to reconcile with her when she befriends all of her classmates in her new middle school class. Even though Bocchi has no faith in herself, she is determined to be friends with Kai again. Summoning all of her courage, Bocchi takes on the daunting challenge of making friends with her entire class, starting with the delinquent-looking girl sitting in front of her...

On the surface, the thought of Kyouko Hori and Izumi Miyamura getting along would be the last thing in people's minds. After all, Hori has a perfect combination of beauty and brains, while Miyamura appears meek and distant to his fellow classmates. However, a fateful meeting between the two lays both of their hidden selves bare. Even though she is popular at school, Hori has little time to socialize with her friends due to housework. On the other hand, Miyamura lives under the noses of his peers, his body bearing secret tattoos and piercings that make him look like a gentle delinquent. Having opposite personalities yet sharing odd similarities, the two quickly become friends and often spend time together in Hori's home. As they both emerge from their shells, they share with each other a side of themselves concealed from the outside world.