The demon Jashin-chan has been summoned to Earth by Yurine Hanazono, a girl with a knack for the occult. Unfortunately, Yurine does not actually know how to send Jashin-chan back to Hell. Now stuck on Earth, she must live at Yurine's apartment as her familiar. The only way for Jashin-chan to return would be to kill her summoner, but this is easier said than done for the incompetent demon. Since Jashin-chan is immortal and can regenerate her body, Yurine does not hold back in attacking her with a range of weapons, punishing her in gruesome manners for her evil schemes. Jashin-chan is also often visited by her demon friends: the kindhearted Gorgon Medusa and the energetic minotaur Minosu, who seem much more well-behaved in contrast, and disapprove of her plans to kill Yurine. Jashin-chan Dropkick is a comedy focusing on these two reluctant roommates and their bizarre antics as they get by with their cat-and-mouse relationship.

People fall in love in the most mysterious of ways. This statement seems to be especially true for the affluent genius playboy Ryou Amakusa. When he nearly falls off the stairs one rainy morning, a girl named Ichika Arima saves him. As if by fate, Ryou encounters Ichika again later that night; she happens to be the best friend of his little sister, Rio. Wanting to "thank" her, Ryou attempts to woo Ichika by employing his usual flirtatious tactics only to be immediately shot down, his target creeped out by his behavior. Rather than being discouraged, Ryou instead becomes more enthralled by her, and he begins to do everything he can to steal Ichika's heart despite receiving disgusted reactions each time. However, as time passes by, will Ichika remain repulsed by Ryou's creepy yet dedicated advances?