Reiji Kirio, formerly a corporate slave, wakes up one day in another world. After discovering that he has gained superhuman pharmaceutical knowledge, he decides to open up a drugstore alongside the canine Noera and the ghostly Mina. There, he tends to the needs of all who visit the shop with potions and the like. Cheat Kusushi no Slow Life: Isekai ni Tsukurou Drugstore follows the slow but often hectic days of Reiji's drugstore.

Haru Yamato was never interested in futsal ever since the sport gained international fame 10 years ago. However, a chance to watch Japanese futsal player Tokinari Tennoji compete at the U-18 World Cup completely changed his perspective. When given the opportunity on his first day at Koyo Gakuen High School, Haru enthusiastically joins the futsal club. There, he meets a variety of talented players including captain Toi Tsukioka, who was a part of the same U-18 team as Tennoji. Despite having a dynamic roster, the Koyo Futsal Club has a long way ahead when it comes to assembling a team that can stand up to powerhouse opponents—especially for Haru, who is a total beginner to the sport!

An established discipline on par with conventional medical approaches, "vocal medicine" is the practice of using songs to treat health conditions and injuries. Young people around the world strive to master the art and become "healers" to help people through the power of their voices. Among the many healers in training is Kana Fujii, a naturally talented singer who was inspired to pursue the profession after a life-changing experience. Along with the driven Reimi Itsushiro and the easygoing Hibiki Morishima, Kana trains at Karasuma Phoniatric Clinic under the stern yet kind mentorship of Ria Karasuma. As they endeavor to achieve their dreams, Kana and her friends meet various colorful healers along the way, discovering that there is much more to vocal medicine than just diligent studying!

Himari Kino is a cheerful and outgoing girl who is able to make friends with anyone she wants. When she enrolls in high school and attends the freshman opening ceremony, Himari falls in love with Yori Asanagi, a reserved upperclassman, during Yori's band performance. After the show, Himari blurts out her love, but Yori is inexperienced when it comes to romance. Yori, who did not expect this outcome at all, looks for answers from her friends and music. She decides to respond to Himari's confession, and to her surprise, Yori discovers that Himari fell in love with her music and performance rather than Yori as a person. Despite the shock, Yori desires to make Himari truly fall in love with her. The duo spend time together after school on the rooftop, where Yori usually plays her guitar with hopes to change Himari's feelings for her.