Ino Sakura has just moved to Tokyo to join the newly formed Fruit Tart, an idol group composed of three members besides herself—Roko Sekino, a washed-up child actor; Hayu Nukui, a failed musician; and Nina Maehara, a model who is still waiting for her first gig. They soon begin their new life together in their dormitory, the Mouse House. But there is no time to get settled as the girls awaken to a shocking reality: Fruit Tart is in a deep debt of one hundred million yen and has not even started yet! With the possibility of Fruit Tart breaking up and the Mouse House being torn down if they cannot repay the money, the girls must work their way up from the bottom of idol society by making a name for themselves and writing their own songs. Luckily, Hemo Midori, an experienced idol, is a huge fan of Sakura and decides to join the group. With smiles on their faces, Sakura and the other girls work hard to become popular idols while making sure that each day is as fun as the last.

For centuries, Heaven has required its young angels to live and study among humans in order to become full-fledged angels. This is no different for top-of-her-class Gabriel White Tenma, who believes it is her mission to be a great angel who will bring happiness to mankind. However, Gabriel grows addicted to video games on Earth and eventually becomes a hikikomori. Proclaiming herself a "Fallen Angel," she is apathetic to everything else—much to the annoyance of Vignette April Tsukinose, a demon whom Gabriel befriended in her angelic early days on Earth. Vignette's attempts to revert Gabriel back to her previous self are in vain, as Gabriel shoots down any attempt to change her precious lifestyle. As they spend their time on Earth, they meet two eccentric personalities: the angel Raphiel Ainsworth Shiraha, Gabriel's classmate with a penchant for sadism, and the demon Satanichia McDowell Kurumizawa, a clumsy self-proclaimed future ruler of the Underworld. Gabriel DropOut follows these four friends' comedic lives as they utterly fail to understand what it truly means to be a demon or an angel.

While reveling in the successful clinching of a prized vase for his collection, Yoshifumi Nitta, a yakuza member, is rudely interrupted when a large, peculiar capsule suddenly materializes and falls on his head. He opens the capsule to reveal a young, blue-haired girl, who doesn't divulge anything about herself but her name—Hina—and the fact that she possesses immense powers. As if things couldn't get any worse, she loses control and unleashes an explosion if her powers remain unused. Faced with no other choice, Nitta finds himself becoming her caregiver. To let her use her powers freely, Nitta asks Hina to help out with a construction deal, which goes smoothly. But while this is happening, a rival yakuza group covertly attacks his boss. To Nitta's shock, his colleagues later pin the blame on him! Tasked with attacking the rival group in retaliation, Nitta steels himself and arrives at their hideout. But suddenly, Hina unexpectedly steps in and helps him wipe out the entire group. As it turns out, Hina might just become a valuable asset to Nitta and his yakuza business, provided she does not use her powers on him first! And so the strange life of this unusual duo begins.

During a regular after-school grub crawl, gluttonous high schooler Hibiki Sakura is confronted about her ever-expanding waistline by her best friend, Ayaka Uehara. With her attempts at solitary exercise failing miserably, Hibiki decides to join the newly opened Silverman Gym. At her orientation, Hibiki runs into student council president and school idol Akemi Souryuuin. However, it soon turns out that Hibiki is in for a lot more than she bargained for. Not only is Silverman Gym full of world-renowned bodybuilders and athletes, but to make matters worse, Akemi turns out to be a total muscle fetishist! Grossed out by the scene unfolding before her eyes, Hibiki begins to leave, only to be stopped by trainer Naruzou Machio. Completely enthralled with her newfound Prince Charming, Hibiki signs up as a gym member. Now, as a result of her spur-of-the-moment decision, Hibiki must adapt to her new lifestyle.