During the early 1930s in Chicago, the transcontinental train, Flying Pussyfoot, is starting its legendary journey that will leave a trail of blood all over the country. At the same time in New York, the ambitious scientist Szilard and his unwilling aide Ennis are looking for missing bottles of the immortality elixir. In addition, a war between the mafia groups is getting worse. On board the Advena Avis, in 1711, alchemists are about to learn the price of immortality. Based on the award-winning light novels of the same name, Baccano! follows several events that initially seem unrelated, both in time and place, but are part of a much bigger story—one of alchemy, survival, and immortality. Merging these events together are the kindhearted would-be thieves, Isaac and Miria, connecting various people, all of them with their own hidden ambitions and agendas, and creating lifelong bonds and consequences for everyone involved.

Daikichi Kawachi is a 30-year-old bachelor working a respectable job but otherwise wandering aimlessly through life. When his grandfather suddenly passes away, he returns to the family home to pay his respects. Upon arriving at the house, he meets a mysterious young girl named Rin who, to Daikichi’s astonishment, is his grandfather's illegitimate daughter! The shy and unapproachable girl is deemed an embarrassment to the family, and finds herself ostracized by her father's relatives, all of them refusing to take care of her in the wake of his death. Daikichi, angered by their coldness toward Rin, announces that he will take her in—despite the fact that he is a young, single man with no prior childcare experience. Usagi Drop is the story of Daikichi's journey through fatherhood as he raises Rin with his gentle and affectionate nature, as well as an exploration of the warmth and interdependence that are at the heart of a happy, close-knit family.

In Tokyo's downtown district of Ikebukuro, amidst many strange rumors and warnings of anonymous gangs and dangerous occupants, one urban legend stands out above the rest—the existence of a headless "Black Rider" who is said to be seen driving a jet-black motorcycle through the city streets. Mikado Ryuugamine has always longed for the excitement of the city life, and an invitation from a childhood friend convinces him to move to Tokyo. Witnessing the Black Rider on his first day in the city, his wishes already seem to have been granted. But as supernatural events begin to occur, ordinary citizens like himself, along with Ikebukuro's most colorful inhabitants, are mixed up in the commotion breaking out in their city.

In the enchanted Kingdom of Fiore, the lively Lucy Heartfilia has one wish: to join the renowned Fairy Tail—one of the many magical wizard guilds scattered around the continent. Luckily, a chance encounter with Natsu Dragneel, the "Salamander" of Fairy Tail, whisks her into the legendary guild. From Natsu's rivalrous antics with ice wizard Gray Fullbuster to the frightening presence of the unmatched combat goddess Erza Scarlet, Fairy Tail's powerful mages have a slight penchant for trouble. Through all the lucrative odd jobs and adventures to save the world from destruction lies an absolute and unyielding trust stronger than family that has formed between each guild member. Teaming up with Natsu, Gray, and Erza, Lucy finds herself amidst the guild's most misfit wizards. But as they constantly stand in the eye of every danger, there is one name that never ceases to resurface: Zeref, the feared master of dark magic.