Attacker You! is the story of ambitious and energetic 13-year-old junior high schoolgirl You Hazuki (variously known as "Mila," "Jeanne" or "Juana" in Western dubbed versions of the anime), who moves to Tokyo from Osaka to live with her father Toshihiko, a cameraman recently returned from Peru, and attend school. You's mother is not in the picture, having left when You was very young. Also living with You and her father is her younger brother Sunny, who is very attached to his older sister and tends to follow her everywhere she goes, including to school and to her volleyball matches. You is also curious about Kyushi Tajima, the pretty blonde woman whom she sees covering volleyball games on television, and about why her father becomes very angry whenever You mentions her. You is passionate about volleyball and dreams of one day being a part of Japan's national women's volleyball team in the 1988 Seoul Olympics. She joins her school's girls' volleyball team and quickly becomes one of the top players, although her coach (who is also her homeroom teacher) is brutal and literally slaps his players around when they don't live up to his expectations. You begins a tumultuous friendship with former school volleyball champ and former arch-rival Nami Hayase (French name: "Peggy"), which comes to a head when the two girls join opposing professional teams. She also develops a crush on So Takiki, the captain of the Hikawa boys' volleyball team (known as "Shiro," "Serge" or "Sergio" in various Western versions), and puts as much effort into trying to win his heart as she does into her game.

The year is 2023 and Alien Beings known as "Lucifer Hawks" have begun invading earth from another dimension. All that stands between them and the enslavement of the human race is the Attacked Mystification Police Department - a special division of the Tokyo Police staffed by women with amazing paranormal abilities. (Source: ANN)

Skull, the evil leader of the terrorist organization known as Black Ghost, has nine powerful cyborgs under his control. But Dr. Isaac Gilmore, the Black Ghosts cybernetics scientist, decides to go rogue, helping the cyborgs turn against Skull and his evil organization. Black Ghost wishes to start the next major world war by flooding the market with weapons of mass destruction. It seems the nine brave cyborgs have their work cut out for them, as Black Ghost is determined to bring those nine cyborgs down.

Mito isn't just another space pirate, she's a three foot tall childlike alien with enough guts to outshine a supernova. She's known as the galaxy's most dangerous pirate, a wanted criminal who destroys a dozen police space cruisers every day before breakfast. But all she really wants is to be called "Mom." (Source: ANN)