In her first life, the renowned and genius surgeon Dr. Aoi Takamoto was Elise de Clorance, a villainess of noble descent. Elise's selfishness, insolence, and obsessive love for her fiancé—Prince Linden de Romanoff—led to the deaths of her family members and, eventually, herself. Only after being reborn did Elise realize the error of her ways and decide that, instead of ruining lives, she would devote herself to saving them. But a tragic airplane crash robs her of her dreams too soon. By a miracle, Elise wakes up in her original body before her official engagement to Linden. Recognizing the chance to cherish her loving family and free Linden from an unwanted marriage, Elise wishes to use her advanced medical knowledge to continue down the path of saving lives. In a deal with the emperor, Elise is given only six months to prove that her true place is not on the throne, but rather with the wounded and ailing who desperately need her help.

Having reached the pinnacle of human potential, Varvatos was so powerful that the rest of humankind began calling him the Demon Lord, both fearing and respecting his overwhelming influence. As a result, he felt alienated from his fellow humans, leading him to desire true companionship—an equal he could call a friend. Hoping his fate will change in his next life, Varvatos decides to start anew and reincarnates three thousand years later as Ard Meteor, the son of a seemingly ordinary couple in a rural town. Unfortunately, he realizes that even after weakening himself, his strength still overshadows everyone in this era. Moreover, his lack of social skills bars him from achieving his goal of making friends. But worst of all, the repercussions of suddenly abandoning his former position have begun to bite him back in some of the most unimaginable ways possible.

The previously bedridden Keina Kagami finds herself in the world of her favorite VRMMORPG—titled Leadale—after the life support keeping her alive fails. Reincarnated in the body of her high-level character, "Cayna," she notices that the world of Leadale is different from what she remembers playing. As she comes to learn, two hundred years have passed since she last interacted with the world. However, this does not sadden Cayna—as it means that a new journey awaits her, filled with exciting prospects and unfamiliar faces all waiting to be discovered.