The ordinary life of 17-year-old otaku Hajime Nagumo is disrupted when he and his classmates are summoned to a fantasy world and tasked with saving mankind. While his classmates are gifted with impressive abilities useful in combat, Hajime is belittled for only gaining an inferior transmutation skill that lacks any real offensive power. During an expedition in the Great Orcus Labyrinth, Hajime is betrayed by one of his classmates, plummeting him to the bottom of an abyss. Though he survives the fall, Hajime is faced with menacing monsters and misfortunes that send him spiraling into a grim nightmare. Desperate to live and return home one day, he resolves to fight for his survival—only to meet an imprisoned vampire he names Yue, who is also seeking to escape the labyrinth. Taking an interest in him, Yue and a few others along the way accompany Hajime on his journey to find a way back home, while steadily transforming from commonplace to the world's strongest.

On the surface, Koudo Ikusei Senior High School is a utopia. The students enjoy an unparalleled amount of freedom, and it is ranked highly in Japan. However, the reality is less than ideal. Four classes, A through D, are ranked in order of merit, and only the top classes receive favorable treatment. Kiyotaka Ayanokouji is a student of Class D, where the school dumps its worst. There he meets the unsociable Suzune Horikita, who believes she was placed in Class D by mistake and desires to climb all the way to Class A, and the seemingly amicable class idol Kikyou Kushida, whose aim is to make as many friends as possible. While class membership is permanent, class rankings are not; students in lower ranked classes can rise in rankings if they score better than those in the top ones. Additionally, in Class D, there are no bars on what methods can be used to get ahead. In this cutthroat school, can they prevail against the odds and reach the top?

The Kazama Family—a gang of three wannabe delinquents and close friends, spearheaded by Kenji Kazama, is trying to make a name for themselves at Fujou Academy. On the first day of the term, the gang finds themselves putting out a fire in the Game Development Club. Instead of thanking them, the eccentric club members attack and knock out Kenji's two friends, forcing Kenji to fight for his life. Failing to escape, the gang leader is coerced into joining the Game Development Club. As he settles in, Kenji gets to know the four girls responsible for his provisional membership—student council president and general tyrant Chitose Karasuyama, spirited tomboy Sakura Mizukami, negligent club advisor Minami Oosawa, and the school's infamous shadow leader Roka Shibasaki. Throughout the Game Development Club's constant shenanigans and his desperate attempts to leave the club, Kenji begins to realize that he may be actually enjoying himself.

Forming a party with one's mother in an online game seems not only unlikely but also uncomfortable to most teenage gamers. Unfortunately, Masato Oosuki finds himself in that exact scenario. After completing a seemingly meaningless survey, he is thrown into the world of a fantasy MMORPG—and his mother Mamako actually tagged along with him! On top of all of that, Mamako turns out to be an overpowered swordswoman, possessing the power of two-hit multi-target attacks! After minor tension between the two, they search for party members, meeting the merchant Porta and the sage Wise, starting their journey to clear the game.