Blue Gender takes place in the not too distant future in a world where things have gone terribly wrong for humanity. Humans have been replaced at the top of the food chain by the Blue, a race of bug-like aliens that have colonized Earth and pushed humans aside. A space station, Second Earth, has been constructed as a safe haven for humans, with the hope of one day reclaiming the Earth once more. Yuji Kaido was cryogenically frozen, having been suffering from a disease known as B-Cells. Once awakened, he joins a team of soldiers that have come to Earth to extract him. Unfortunately, nothing goes according to plan as they make their way back to Second Earth. Yuji will have to deal with the horrors of fighting a bloody war as he and the fighters from Second Earth look to survive. Will they be able to win back Earth without losing their humanity?

One sunny day invaders came from space. They weren't little green men or funny girls wearing school uniforms, though. They were ugly robots which defeated the UN forces in seconds. After that the invaders (known as "eyeballs") roamed around and observed human society. In fact, they were peaceful unless attacked. They were polite and followed all the traffic laws, too. Still, they were aliens and the people of Earth wanted them to go home. The Kitanohashi High School Magic Club took it on themselves to defeat these foul robots and free the world. (Source: ANN)