Mitsuha Miyamizu, a high school girl, yearns to live the life of a boy in the bustling city of Tokyo—a dream that stands in stark contrast to her present life in the countryside. Meanwhile in the city, Taki Tachibana lives a busy life as a high school student while juggling his part-time job and hopes for a future in architecture. One day, Mitsuha awakens in a room that is not her own and suddenly finds herself living the dream life in Tokyo—but in Taki's body! Elsewhere, Taki finds himself living Mitsuha's life in the humble countryside. In pursuit of an answer to this strange phenomenon, they begin to search for one another. Kimi no Na wa. revolves around Mitsuha and Taki's actions, which begin to have a dramatic impact on each other's lives, weaving them into a fabric held together by fate and circumstance.

Hiroki Fujisawa and Takuya Shirakawa harbor admiration for two things in their life: their classmate Sayuri Sawatari and the vast Ezo Tower that stands boundlessly across the Tsugaru Strait. Fascinated by the limitless structure beyond their reach, Hiroki and Takuya begin constructing an aeroplane from a fallen drone they discovered—naming it the Bella Ciela—to fulfill their dream of one day reaching the sky-scraping top of the tower. Later joined by the girl they love, Hiroki and Takuya promise Sayuri to fly with her to the seemingly otherworldly top together. However, Japan has suffered a North-South partitioning that has fueled conflict near the base of the tower, which marks the border between the America-controlled Southern islands and the Northern lands occupied by the Soviet Union. Further along, Sayuri suddenly disappears, and Hiroki and Takuya never see her again. Unbeknownst to them, she fell victim to a sleeping disorder that left her comatose for the past three years. Although Hiroki and Takuya later learn about Sayuri's condition, they also discover that the girl's unconscious state is oddly linked to the same tower the trio had promised to conquer together.

In near-future Japan, Aya Okamura lives alone in an apartment away from her parents. Her mother has worked overseas ever since her childhood, so her aging father Kouji and their cat Mii-san are the only ones left in their family home. After a tiring day, Aya declines her father's invitation for dinner by lying that she is still at work. Yet that very night, she receives another call with sudden news that may bring this separated family closer.

If you could turn all your memories into a song, what would it resemble? Between being an exceptional student and taking care of the house alone during her mother's absence, Asuna Watase's only distraction is listening to her old crystal radio in her secret mountain hideout. One day, she accidentally tunes to a mysterious and melancholic melody, different from anything she has ever heard before. Soon after, an enigmatic boy named Shun saves her from a dangerous creature, unknowingly dragging Asuna on a long journey to a long lost land bound to surpass her very imagination, turning her once melodic life into an intricate requiem.