Kusuo Saiki is a high school student who possesses a wide range of psychic abilities. While many may believe these abilities to be a gift, to Kusuo, they are a curse as he must fight strange odds in order to try to live a normal life. Forced to use his psychic powers to protect his secret or to make up for his father's incompetence at work, will Saiki eventually come to realize how his powers can actually help his friends and family?

The ground shakes, a rumble follows, and before anyone in Japan can prepare themselves, a cataclysmic volcanic eruption engulfs the country in molten lava and suffocating ashes. Of course, high school student Kusou Saiki repeatedly uses his psychic powers to prevent this harrowing catastrophe. But between restoring the planet and watching his friends discuss their aspirations, Saiki finally resolves to stop the eruption and allow the world to continue spinning. However, this straightforward task is challenging even for the most powerful of psychics, let alone one who must deal with the usual shenanigans his ludicrous friends present.

To the average person, psychic abilities might seem a blessing; for Kusuo Saiki, however, this could not be further from the truth. Gifted with a wide assortment of supernatural abilities ranging from telepathy to x-ray vision, he finds this so-called blessing to be nothing but a curse. As all the inconveniences his powers cause constantly pile up, all Kusuo aims for is an ordinary, hassle-free life—a life where ignorance is bliss. Unfortunately, the life of a psychic is far from quiet. Though Kusuo tries to stay out of the spotlight by keeping his powers a secret from his classmates, he ends up inadvertently attracting the attention of many odd characters, such as the empty-headed Riki Nendou and the delusional Shun Kaidou. Forced to deal with the craziness of the people around him, Kusuo comes to learn that the ordinary life he has been striving for is a lot more difficult to achieve than expected.

The disastrous life of the gifted psychic Kusuo Saiki continues, despite his utmost effort to live an ordinary life. Although he has certainly grown accustomed to dealing with his troublesome friends—who are his biggest hurdle to achieving a peaceful life—he still has a long way to go. Also joining the usual oddballs are a few new faces whose shenanigans add to Saiki's misery, making his dreams of a hassle-free life a distant fantasy.