In the newly formed Shiniki district of Tokyo, Zen Seizaki is a diligent public prosecutor at the Tokyo District Public Prosecutors Office. Assigned to a case involving false advertisement, Zen—along with his assistant officer, Atsuhiko Fumio—investigate Japan Supiri, a pharmaceutical company that had provided fabricated clinical research on the company's new drug. While investigating the file of Shin Inaba, an anesthesiologist connected to the crime, the case takes a dark turn when Zen finds a page stained with a mixture of blood, hair and skin, along with the letter "F" scribbled all across the sheet. As he investigates further, the case goes beyond Zen's imagination and becomes vastly complex, challenging his sense of justice and his knowledge of the truth. Digging deeper into the investigation, Zen begins to uncover a concealed plot behind the ongoing mayoral election and ties to many people of interest involved in the election and those closer than he thinks. The case grows more severe and propels Zen into an unforeseen hurricane of corruption and deceit behind the election, the establishment of the Shiniki district, and the mysterious woman associated with it all.

In role-playing games, slimes are usually the easiest monster to kill, and because of that, they yield few experience points. But what would happen if you live long enough to keep defeating them for 300 years? After many years of being a corporate slave, Azusa Aizawa abruptly passes away due to severe exhaustion. Seemingly headed for the afterlife, she meets a goddess who bestows her with immortality alongside a peaceful life in another world. There, Azusa enjoys her days tending to her farm, protecting the nearby village, and killing about 25 slimes per day—a routine that continues for at least three centuries. However, this rather monotonous cycle begins to change when Azusa suddenly finds out that she has reached level 99—the maximum possible level—from slimes alone. Despite desperately trying to hide this fact in fear of ending her slow life, rumors of her strength spread nevertheless. Soon enough, various people throughout the continent, like the dragon Laika and the elf Halkara, start to appear at her doorstep—some seeking a battle, others asking for her assistance. Meeting friends and acquaintances who soon become family, Azusa finds she can live a life far better with others than when she was alone.

After working himself to death in a hostile corporate environment, Yuuji Sano gets a second chance when he transmigrates to a game-like fantasy world. Although he wishes to lead an unassuming life, Yuuji learns that he has the title of a Monster Tamer, the weakest rank of adventurer. With his newfound skills, he tames a number of slimes around him and, with their help, acquires magical powers to become a Sage—a second profession that capitalizes on such potential. Even after gaining overwhelming strength, the scars from the life Yuuji left behind keep him from going all out. However, he might not be able to hide his abilities for much longer, as unforeseen dangers threaten to destroy the world that is now his only home.