Devils cannot take form without a living host. However, if the will of an individual is strong enough, they can overcome the demon and make its power their own, becoming a Devilman. Weak and unassuming, Akira Fudou has always had a bleeding heart. So when his childhood friend Ryou Asuka asks for his help in uncovering devils, Akira accepts without hesitation. However, to Akira's surprise, the place they go to is Sabbath: an immoral party of debauchery and degeneracy. Amidst bloodshed and death, demons possess the partiers, turning their bodies into grotesque monsters, and begin wreaking havoc. In a reckless attempt to save his best friend, Akira unwittingly merges with the devil Amon and becomes a Devilman, gaining the power to defeat the remaining demons. Though it grants him great power, this new partnership awakens an insatiable and primeval part of Akira. Having the body of a devil but the same crybaby heart, Akira works alongside Ryou, destroying those that harm humanity and his loved ones.

After being aggressively rejected, Momo Ayase finds herself sulking when she stumbles across a boy being bullied. Saved by her rash kindness, the alien-obsessed boy attempts to speak to her about extraterrestrial interests he believes they share. Rejecting his claims, Ayase proclaimed that she instead is a believer in ghosts, starting an argument between the two over which is real. In a bet to determine who is correct, the two decide to separately visit locations associated with both the extraterrestrial and the supernatural—Ayase visiting the former and the boy visiting the latter. When the two reach their respective places, it turns out that neither was wrong and that both aliens and ghosts do exist. This marks the beginning of Ayase and the boy's adventure, as they attempt to fix the surreal, supernatural, and extraterrestrial elements around them to return to a normal life.

Entranced by surfing and the sea, Hinako Mukaimizu is a spirited girl who attends college in a coastal city with no consideration for her future career. Her life takes an unexpected turn when a fireworks mishap sets the apartment building she lives in ablaze, where she is saved by a talented firefighter named Minato Hinageshi. Upon meeting, the two quickly become acquainted with one another—Hinako is instantly enamored by Minato's reliable personality and passion for saving others, while Minato is intrigued by surfing and is eager to learn how. As Hinako begins to teach Minato about surfing, the pair eventually fall in love and begin a gentle and devoted relationship. However, while surfing may seem fun and carefree, it can still be a dangerous and unpredictable activity. This is what Hinako learns when a surfing incident completely changes her life, leaving her forced to contemplate her undecided future. In search of her own calling, Hinako begins her journey of self-discovery, keeping Minato by her side as she gradually attempts to find her purpose and ride her own wave.

Midori Asakusa sees the world a bit differently. Always having her nose in a sketchbook, Asakusa draws detailed landscapes and backgrounds of both the world around her and the one within her boundless imagination. Even the simple act of doodling on a wall evolves into an emergency repair on the outer hull of her spaceship. She is only brought back to reality by her best friend Sayaka Kanamori. The pair are stark opposites, with Asakusa's childlike wonder contrasted by Kanamori's calculated approach to life. After a chance encounter where the two "save" the young model Tsubame Misuzaki from her overprotective bodyguard, a connection instantly sparks between Asakusa and Misuzaki, as both share an intense passion for art and animation. Whereas Asakusa is interested in backgrounds and settings, Misuzaki loves drawing the human form. Sensing a money-making opportunity, Kanamori suggests that they start an animation club, which they disguise as a motion picture club since the school already has an anime club. Thus begins the trio's journey of producing animation that will awe the world. From the brilliant mind of Masaaki Yuasa, Eizouken ni wa Te wo Dasu na! is a love letter to animation, wildly creative in its approach, and a testament to the potential of the medium.