Continuing after the Level Upper incident, another phenomenon torments Misaka. A phenomenon called "Someone's Watching," its effect feels like the electricity in one's body flow backwards. With the help of her friends, Misaka fights against the unknown enemy.

Simon and Kamina were born and raised in a deep, underground village, hidden from the fabled surface. Kamina is a free-spirited loose cannon bent on making a name for himself, while Simon is a timid young boy with no real aspirations. One day while excavating the earth, Simon stumbles upon a mysterious object that turns out to be the ignition key to an ancient artifact of war, which the duo dubs Lagann. Using their new weapon, Simon and Kamina fend off a surprise attack from the surface with the help of Yoko Littner, a hot-blooded redhead wielding a massive gun who wanders the world above. In the aftermath of the battle, the sky is now in plain view, prompting Simon and Kamina to set off on a journey alongside Yoko to explore the wastelands of the surface. Soon, they join the fight against the "Beastmen," humanoid creatures that terrorize the remnants of humanity in powerful robots called "Gunmen." Although they face some challenges and setbacks, the trio bravely fights these new enemies alongside other survivors to reclaim the surface, while slowly unraveling a galaxy-sized mystery.

Animation studio Gainax presented a website for the release of a movie adaptation of the Tengen Toppa Gurren Lagann TV series in the fall of 2008. Both the original director and series script editor will return to work on the new project. Gainax will also be hosting four events to celebrate this occasion at this year's Tokyo International Anime Fair, featuring voice actors from the anime.

Humans have enjoyed their lavish, peaceful, and prosperous lives for seven years since the day the almighty Spiral King was defeated—the day they reclaimed their homeland, Earth. However, the boon of this lifestyle leaves them unprepared when an unknown, hostile threat arises due to the ever-growing human population. This calamity is the Anti-Spiral—a fearsome enemy with unparalleled power. As the Spiral King's prognosis postulating the destruction of "The Spiral's World" begins to come true, the pieces are in place, and Team Dai-Gurren is ready. With his late brother's hope to see a better future for mankind, Simon—along with Nia Teppelin and the rest of the team—is determined to overthrow the mighty Anti-Spiral in order to revive humanity's lost hope.