In a world of magic and monsters, Krylancelo Finrandi and his foster sister Azalie Cait-Sith were once promising students of sorcery, prodigies at the famous Tower of Fangs. But an experiment gone horribly wrong warps Azalie's appearance, trapping her in the form of a dragon. Elders at the Tower—more interested in preserving their reputation rather than their students' lives—drive off the transformed Azalie and cover up the incident. Outraged, Krylancelo strikes out on his own, taking the new name of "Orphen" and vowing to return Azalie to her normal state. Five years later, Orphen's quest has stalled. A chance encounter brings him face to face with Azalie again, but he still has no way to restore her body. And with a hostile group of sorcerers hunting her down, he may be running out of time. The past and present collide as Orphen tries to find how to save Azalie from their former teachers and friends.

Fifty years ago, horrific creatures dubbed as the "enemies of humanity" suddenly appeared around the world. To combat these threats, teenagers gifted with supernatural abilities called "Talents"—such as pyrokinesis and time travel—hone their powers at an academy on a secluded island. Nanao Nakajima, however, is quite different from the others on the island: he has no Talent. With many "Talented" teenagers around him, Nanao is often a target for bullying, but even so, he still strives to complete his training. Soon after, two transfer students, the mysterious Kyouya Onodera and the mind-reading Nana Hiiragi, join the class. But just as everyone starts blending as comrades-in-arms, mysterious disappearances begin to threaten the class's entire foundation.

When Myne learns that the Holy Church is in need of mana for their relics, she sees it as her chance to be cured of her life-threatening mana disorder. After seeing their bountiful library, she throws herself headfirst into the Church's grasp and begs to join their order. In exchange for her service and her unusually bountiful supply of mana, Myne is given the blue robes of a noble-born apprentice priestess, despite being a commoner. To Myne, all this talk of mana and nobility is trivial, as she now has access to an unlimited supply of books! As Myne transitions into the next phase of her life in this new world, she soon learns that achieving her dream has come at a heavy cost. Noble society is severe, unforgiving, and fueled by politics and neglect. She must now deal with the class conflict between the noble-born blue robes and the common-born grey robes, the High Priest's attempts to oust her, and constant behavioral issues from her new retainers. With the help of her family, friends, and the enigmatic Head Priest whose loyalties and motives remain unknown, Myne seeks to overcome these obstacles and continue on the path to becoming her ideal self—the ultimate librarian!