In class 3-3 of Yomiyama North Junior High, transfer student Kouichi Sakakibara makes his return after taking a sick leave for the first month of school. Among his new classmates, he is inexplicably drawn toward Mei Misaki—a reserved girl with an eyepatch whom he met in the hospital during his absence. But none of his classmates acknowledge her existence; they warn him not to acquaint himself with things that do not exist. Against their words of caution, Kouichi befriends Mei—soon learning of the sinister truth behind his friends' apprehension. The ominous rumors revolve around a former student of the class 3-3. However, no one will share the full details of the grim event with Kouichi. Engrossed in the curse that plagues his class, Kouichi sets out to discover its connection to his new friend. As a series of tragedies arise around them, it is now up to Kouichi, Mei, and their classmates to unravel the eerie mystery—but doing so will come at a hefty price.

For weeks, Atsushi Nakajima's orphanage has been plagued by a mystical tiger that only he seems to be unaware of. Suspected to be behind the strange incidents, the 18-year-old is abruptly kicked out of the orphanage and left hungry, homeless, and wandering through the city. While starving on a riverbank, Atsushi saves a rather eccentric man named Osamu Dazai from drowning. Whimsical suicide enthusiast and supernatural detective, Dazai has been investigating the same tiger that has been terrorizing the boy. Together with Dazai's partner Doppo Kunikida, they solve the mystery, but its resolution leaves Atsushi in a tight spot. As various odd events take place, Atsushi is coerced into joining their firm of supernatural investigators, taking on unusual cases the police cannot handle, alongside his numerous enigmatic co-workers.

Despite their differences in position, three men—the youngest senior executive of the Port Mafia, Osamu Dazai; the lowest ranking member, Sakunosuke Oda; and the intelligence agent, Ango Sakaguchi—gather at the Lupin Bar at the end of the day to relax and take delight in the company of friends. However, one night, Ango disappears. A photograph taken at the bar is all that is left of the three together. Fast forward to the present, and Dazai is now a member of the Armed Detective Agency. The Guild, an American gifted organization, has entered the fray and is intent on taking the Agency's work permit. They must now divide their attention between the two groups, the Guild and the Port Mafia, who oppose their very existence.

Angelise Ikaruga Misurugi is the first princess of the noble Misurugi Empire. The kingdom has seen great power and prosperity due to the advancement of the revolutionary technology known as "Mana," an abstract bending of light that has reduced the world's problems of war and pollution to a timeless peace. However, not all are blessed with the ability to wield Mana. Those who cannot are labeled "Norma," outcasts of society who are considered a threat to civilization and live under constant persecution, and Angelise herself is one of many who want the Norma exterminated. But as Angelise's sixteenth birthday commences, it is discovered in a shocking revelation that she is actually a Norma. Chaos ensues, the public is outraged, and the once adored princess is exiled to Arzenal: a remote military base where Normas are forced into conscription. Now, the former royal must adapt to a harsh and vastly different lifestyle; piloting mechanical robots known as "Paramail" to fend off large, devastating beasts referred to as DRAGONs. However, a sinister truth about these savage creatures threatens to change everything.