Long before the era of prehistoric man, an advanced alien species inhabited Earth. Negligent of the power they held, these beings ultimately caused their own demise. However, the aliens left behind a warning to future civilizations on indestructible tablets: to destroy any remains of the ruinous technology created by their kind. In modern times, the ARCAM Corporation and their paramilitary unit—the Spriggans—seek to seal the relics away and prevent renegade actors from exploiting their powers. Following ARCAM's recent discovery in the Ararat Mountains of what is believed to be the mythic Noah's Ark, Spriggan Yuu Ominae has been dispatched to investigate. However, the site is ambushed by the US Machine Corps—a radical faction of the Department of Defense led by Colonel MacDougall. On the Pentagon's orders, MacDougall seeks to secure ARCAM's lead scientist and seize the artifact. Teamed up with fellow Spriggan Jean Jacquemondo, Yuu must stop MacDougall and the Machine Corps' elite soldiers from advancing on the Ark before it is too late.

At the turn of the millennium, Ginei Studio's dilapidated buildings are set to be demolished. Ex-employee and filmmaker Genya Tachibana decides to honor this occasion with a commemorative documentary about the company's star actress: Chiyoko Fujiwara, the reclusive sweetheart of Shouwa Era cinema. Having finally obtained permission to interview the retired starlet, an enamored Genya drags along cynical cameraman Kyouji Ida to meet her, ready to put his lifelong idol back in the spotlight once more. Hidden in this secluded mountain retreat is a thousand years of history condensed into one lifetime, waiting to be narrated. Chiyoko's recollections take them on an illusionary journey through Japanese cinematic history that transcends the boundaries of reality; the saga of her acting career intertwines with her filmography, the actors in her life blend seamlessly with the characters on screen, and the present melds with the past. Though the actress may have retired at the height of her career 30 years ago, the curtain on her life's stage has yet to fall.

Crime is timeless. By the year 2071, humanity has expanded across the galaxy, filling the surface of other planets with settlements like those on Earth. These new societies are plagued by murder, drug use, and theft, and intergalactic outlaws are hunted by a growing number of tough bounty hunters. Spike Spiegel and Jet Black pursue criminals throughout space to make a humble living. Beneath his goofy and aloof demeanor, Spike is haunted by the weight of his violent past. Meanwhile, Jet manages his own troubled memories while taking care of Spike and the Bebop, their ship. The duo is joined by the beautiful con artist Faye Valentine, odd child Edward Wong Hau Pepelu Tivrusky IV, and Ein, a bioengineered Welsh Corgi. While developing bonds and working to catch a colorful cast of criminals, the Bebop crew's lives are disrupted by a menace from Spike's past. As a rival's maniacal plot continues to unravel, Spike must choose between life with his newfound family or revenge for his old wounds.

Kyoto has been populated by groups of tanuki and tengu for years, living alongside humans who are oblivious to the existence of these creatures. Yasaburou Shimogamo is the third son of an influential tanuki family who spends his carefree days taking care of an old tengu, observing humans through his ability to shapeshift, and dealing with the mysterious woman named Benten. Behind the peace and tranquility, however, is a painful memory from long ago as Yasaburou's father, head of the tanuki community, was killed and eaten by a group of humans known as the Friday Fellows. Uchouten Kazoku follows the trials and tribulations of the Shimogamo brothers as they struggle to avoid their own grisly demise while coming ever closer to unraveling the truth behind their father's death.