Academy City, Japan, is at the forefront of science. Besides being 30 years ahead of the world technologically, more than three-fourths of this peculiar city's population consists of students developing their psychic abilities as espers in various institutions. Among these students is Touma Kamijou, a high school boy with the lowest psychic rank of zero, but with a mysterious power no scientist can understand: "Imagine Breaker," which allows him to negate other supernatural abilities. This, however, doesn't affect Kamijou's life in the least as he plays his role as a regular teenager; that is, until he meets the strange Index Librorum Prohibitorum, a young girl who has memorized the entirety of the forbidden grimoires, and now a dangerous organization is hunting Index down. With several magicians looking to harm the girl, Kamijou will defend his new companion at all costs as he discovers a strange new realm of the supernatural.

The blockheads of Class F return with more misadventures! Rather than desperately competing against the elite students in Class A for better facilities, they have other problems at hand. While the girls are constantly vying for the boys' attention, Akihisa Yoshii and Yuuji Sakamoto are being blackmailed by a stalker who threatens to reveal their most embarrassing secrets to the whole school. Moreover, everyone's avatar starts to behave strangely. Filled with more nosebleeds and eye-pokes, the boys of Class F must work together to discover the stalker's identity and deal with the misfortunes that come with love among fools.

The "Anarchy Sisters," Panty and Stocking, have been kicked out of Heaven for, to put it mildly, misbehaving. Led by a priest named Garterbelt, these angels must buy their way back by exterminating ghosts in Daten City. But this task requires unconventional weapons for these unorthodox angels—they transform their lingerie into weapons to dispatch the spirits. Unfortunately, neither of them take their duties seriously, as they rather spend their time in pursuit of other "hobbies": Panty prefers to sleep with anything that walks, and Stocking favors stuffing her face with sweets than hunting ghosts. Follow these two unruly angels as they battle ghosts, an overflow of bodily fluids, and their own tendency to get side-tracked in Panty & Stocking with Garterbelt.