Every Thursday, Shuchiin Academy student council secretary Yuu Ishigami can be found in a state of anxiety. He counts down the hours until he can escape to the student council chamber to read the latest chapter of the popular seinen manga series, "Momo Doesn't Think." Joining Ishigami in his weekly reading, student council president Miyuki Shirogane swiftly grows excited at the news of a third season of the manga's anime adaptation. However, it is only a matter of time before vice president Kaguya Shinomiya discovers what has been engrossing the two boys. With the stigma of being labeled an otaku looming over his head, Shirogane must do everything he can to keep his embarrassing secret from coming to light.

Kyoto has been populated by groups of tanuki and tengu for years, living alongside humans who are oblivious to the existence of these creatures. Yasaburou Shimogamo is the third son of an influential tanuki family who spends his carefree days taking care of an old tengu, observing humans through his ability to shapeshift, and dealing with the mysterious woman named Benten. Behind the peace and tranquility, however, is a painful memory from long ago as Yasaburou's father, head of the tanuki community, was killed and eaten by a group of humans known as the Friday Fellows. Uchouten Kazoku follows the trials and tribulations of the Shimogamo brothers as they struggle to avoid their own grisly demise while coming ever closer to unraveling the truth behind their father's death.