Kaoruko "Chaos" Moeta is a young manga artist who is down on her luck. She wants to draw manga about high school girls, but her storyboards are bland, her art uninspired, and her premises weak. Her concerned, exasperated editor comes up with an idea: push Chaos to be more social. So, by her recommendation, Chaos moves into a dormitory for female manga artists. She soon meets the other residents: Tsubasa Katsuki, a shounen manga artist; Ruki Irokawa, who draws erotic manga popular with women; and Koyume Koizuka, a shoujo artist who, like Chaos, has yet to be serialized. Quickly striking up a friendship with these girls, Chaos finds new inspiration for her manga and continues to grow her creativity. Comic Girls is a showcase of the daily lives of these manga artists. Will Chaos finally be able to make her debut and become serialized? None of the girls know, but they will all do their best to help each other become the best artists they can be.

On the surface, the thought of Kyouko Hori and Izumi Miyamura getting along would be the last thing in people's minds. After all, Hori has a perfect combination of beauty and brains, while Miyamura appears meek and distant to his fellow classmates. However, a fateful meeting between the two lays both of their hidden selves bare. Even though she is popular at school, Hori has little time to socialize with her friends due to housework. On the other hand, Miyamura lives under the noses of his peers, his body bearing secret tattoos and piercings that make him look like a gentle delinquent. Having opposite personalities yet sharing odd similarities, the two quickly become friends and often spend time together in Hori's home. As they both emerge from their shells, they share with each other a side of themselves concealed from the outside world.

Ren Fujii is a normal student who just had a fistfight with his former best friend, leading him to break off their friendship. But with the help of his childhood friend, Kasumi Ayase, and upperclassman, Rea Himuro, he's gradually returning to his normal school life. Then a series of brutal murders in which the victims are decapitated begins to strike their city. Strangely, at the same time, Ren starts to have terrifying nightmares of being beheaded by a guillotine. But these are just a prelude to the painful and terrifying battles to come. (Source: Crunchyroll)

Throughout history, an elite group of shrine maidens known as "Toji" have saved the world from "Aratama," strange and malevolent beings bent on destroying humanity. In modern times, these warriors have been assigned to a special police squad to exterminate Aratama. The government has also set up five elite schools across the country to provide young girls the necessary sword fighting skills to eradicate these monsters and eventually join their fellow Toji in protecting the world. A student of one of those five schools, Kanami Etou is chosen to represent Minoseki Academy in a sword fighting tournament, where she meets the mysterious Hiyori Juujou. Although Kanami and Hiyori rise to the top of the tournament, their battle takes an unexpected turn, throwing the world of the Toji into chaos. Likely that the Toji are facing betrayal from within, the two are forced to flee the tournament, clashing with former comrades on the way.