Daikichi Kawachi is a 30-year-old bachelor working a respectable job but otherwise wandering aimlessly through life. When his grandfather suddenly passes away, he returns to the family home to pay his respects. Upon arriving at the house, he meets a mysterious young girl named Rin who, to Daikichi’s astonishment, is his grandfather's illegitimate daughter! The shy and unapproachable girl is deemed an embarrassment to the family, and finds herself ostracized by her father's relatives, all of them refusing to take care of her in the wake of his death. Daikichi, angered by their coldness toward Rin, announces that he will take her in—despite the fact that he is a young, single man with no prior childcare experience. Usagi Drop is the story of Daikichi's journey through fatherhood as he raises Rin with his gentle and affectionate nature, as well as an exploration of the warmth and interdependence that are at the heart of a happy, close-knit family.

Ryousuke Hazuki is a young man whose heart has been stolen away, stopping by the local floral shop daily in order to catch a glimpse of the beautiful Rokka Shimao, the shop's owner. In hopes of getting close to her, he decides to get a part-time job at the shop, but before he is able to make his move, he runs into a major roadblock: in her apartment dwells a ghost who claims to be Rokka's deceased husband. Atsushi Shimao has quietly watched over his widowed wife ever since he passed three years ago. However, Hazuki is the first person to ever notice him, and the two quickly find themselves at odds: the jealous Shimao attempts to thwart the suitor's advances and possess his body, while Hazuki simply wants the ghost to pass on for good, allowing Rokka to move on from the past and him to be with the one he loves. As both men refuse to let go of their desires, an unusual relationship forms between a troubled woman, an unrelenting ghost, and a stubborn man in love.

On her way home from school, Yukari Hayasaka is approached by a weird-looking guy who starts looking at her body intently. He's got blond spiky hair, a spiked choker, and multiple piercings on his ears and face. She wants nothing to do with him, and runs away, only to bump into a very tall and beautiful purple-haired woman with a flower pattern around her eye. Yukari faints from shock and wakes up later in a strange place called the Atelier. It turns out that these strangers are fashion designers who attend the most famous art school around, Yazawa Art Academy, and their group wants Yukari to model for their brand in Yazawa Academy's upcoming show. Yukari turns down their offer and escapes the Atelier, but unknowingly leaves her school ID behind. George Koizumi, the head designer, later sees it and immediately knows she would be the perfect model for them and will not stop until he gets what he wants—and he wants her. Yukari had never considered something as frivolous as modeling before, but could life among these eccentric designers actually prove to be fun? Or will Yukari lose herself in this world of art and passion?