Ayakashi are strange, supernatural creatures invisible to the majority of people. Though most are harmless, some ayakashi attack humans to devour their life force. Exorcist ninjas are tasked with protecting people from these spiteful spirits. Matsuri Kazamaki is a young exorcist ninja born to a prestigious clan. His childhood friend, Suzu Kanade, is an ayakashi medium—an individual with immense vitality that attracts ayakashi. Matsuri deems all ayakashi threatening and wishes to keep Suzu as far from them as possible, but this clashes with her desire to remain close to them. One day, the pair encounters Shirogane, the "King of Ayakashi," who is hellbent on consuming Suzu. As she is about to be eaten, Matsuri comes to the rescue and manages to seal the ayakashi's powers—but not before Shirogane takes revenge by turning him into a girl! Until he finds a way to transform back, Matsuri must adjust to his new, peculiar lifestyle while fighting against hostile ayakashi. Moreover, Suzu is now conflicted about her feelings toward Matsuri—further plunging their relationship into a state of ambiguity.

Ichirou Suzuki, a programmer nearing his thirties, is drowning in work. Worn out, he eventually has a chance to catch up on sleep, only to wake up and discover himself in a fantasy RPG world, which is mashed together from the games he was debugging in reality. In this new place, he realizes that not only has his appearance changed to a younger version of himself, but his name has also changed to Satou, a nickname he used while running beta tests on games. However, before Satou can fully grasp his situation, an army of lizardmen launch an assault on him. Forced to cast a powerful spell in retaliation, Satou wipes them out completely and his level is boosted to 310, effectively maximizing his stats. Now, as a high-leveled adventurer armed with a plethora of skills and no way to return to reality, Satou sets out to explore this magical new world.

Experienced voice actor Yasumi Utatane works hard to maintain her image as a pure and innocent idol to please her fans, even as she struggles to find more jobs in the industry. But Yasumi has a secret—she is actually Yumiko Satou, a high school girl who prefers loose clothes and flashy jewelry, a complete contradiction to her false professional persona. As Yasumi, Yumiko is finally offered an exciting opportunity to do a radio program alongside another up-and-coming voice actor she admires: Yuuhi Yuugure. In Yumiko’s eyes, Yuuhi’s cute looks and talented acting embody what a voice actor should be. As soon as they are introduced at the recording studio, however, Yumiko realizes that Yuuhi is actually her gloomy classmate, Chika Watanabe. Together, the pair commit to their radio program and slowly begin to open up. In supporting each other, Yumikoi and Chika gradually learn to be true to themselves.

Five separate worlds—Black, White, Green, Red, and Blue—are linked by the "Halo" and exist in a harmonious balance. However, the Halo suddenly opens in an event known as the World Connect, threatening to destroy the universe. Coming under attack by Ouroboros, an alien species that wishes to accelerate the universe's end, the five worlds recruit girls with special abilities called Exceed to defend against them. Saya Sougetsu, a young girl from the Blue World of Earth, is one such individual able to wield Exceed power. Believing this to be her chance to make a difference, Saya eagerly joins the defense force. There, she meets Amane Ayashiro, another girl from Earth, as well as a selection of fighters from the other worlds. Faced with a formidable foe, the girls must prove that their newfound bonds are strong enough to save the future.