At first glance, Ramune may not seem like a professional doctor—he is crass, rude, and often acts halfheartedly. But his true brilliance shines through once his patients pay him a visit: he is able to diagnose and treat all sorts of strange, mysterious diseases that come his way. From a young student whose fingers have turned into chili peppers to a child whose tears are made of condiments, Ramune is able to tap into a kind of innate, otherworldly sensibility that enables him to decipher the roots of their source. But finding the proper cure for these illnesses comes at a valuable price, and money certainly cannot be used to pay it.

Vampires walk among society, existing as part of its underbelly. They do not require blood to survive, but extreme emotions can immensely increase their bloodlust, turning them into uncontrollable monsters. Tsukasa Taira, a 22-year-old university student, learns of the existence of vampires when her longtime friend reveals himself to be one of them after a tense confrontation with Yuuki Anzai—a human and vampire hybrid. Her friend is arrested, and Tsukasa soon finds herself drawn to Anzai, who reluctantly reciprocates her feelings. However, this unconventional romance may prove too difficult to maintain, as Anzai struggles to contain the part of him that wishes to devour Tsukasa.

The Servamps and their pact-bound "Eves" are finally getting back to their normal lives as they recover from their injuries from the previous battles. However, when it starts snowing in the middle of summer, one of the Eves, Mahiru Shirota, suspects vampiric interference. Concerned by the strange phenomenon, he sets out to gather the group once more to try and solve the mystery; however, they suddenly lose contact with Misono Arisuin, the Eve of the Servamp of Lust. Servamp Movie: Alice in the Garden delves into the untold past of Misono and his brother Mikuni Arisuin, as well as the many mysteries of the grand Arisuin Mansion.

Gen Kudou, a koto maker, believes that his delinquent grandson Chika would never understand the profoundness of the traditional musical instrument. In an attempt to make up for his naivety and understand the words of his late grandfather, Chika tries to join the Tokise High School Koto Club. Even though the club is in dire need of members, new club president Takezou Kurata is unwilling to easily accept Chika's application due to his bad reputation. Nonetheless, after seeing Chika's seriousness and enthusiasm, Takezou allows the problem child to join, along with koto prodigy Satowa Houzuki and three of Chika's energetic friends. Kono Oto Tomare! follows the merry band of musicians as they aspire to play at the national competition.