Patema is a plucky young girl from an underground civilization boasting an incredible network of tunnels. Inspired by a friend that mysteriously went missing, she is often reprimanded due to her constant excursions of these tunnels due to her royal status. After she enters what is known as the "forbidden zone," she accidentally falls into a giant bottomless pit after being startled by a strange creature. Finding herself on the surface, a world literally turned upside down, she begins falling towards the sky only to be saved by Age, a discontented student of the totalitarian nation known as Aiga. The people of Aiga are taught to believe that "Inverts," like Patema, are sinners that will be "swallowed by the sky," but Age has resisted this propaganda and decides to protect his new friend. A chance meeting between two curious teenagers leads to an exploration of two unique worlds as they begin working together to unveil the secrets of their origins in Sakasama no Patema, a heart-warming film about overcoming differences in order to coexist.

An OVA based on the Hoshi no Umi arc of the manga spanning chapters 26-34. This arc focuses on Rin Azuma, a Jiang-Shi yokai resident of Sakurashin adjusting to her new life in the city and working for a ramen shop. One day her former friend Zakuro Kurumaki invades Sakurashin to capture Rin and convince her to join her in destroying the city with the other yokai hunters as well as Enjin Hiizumi, the main antagonist of the series. Akina Hiizumi and the other members of the Hiizumi Life Counseling Office take action to save Rin, 'tune' the yokai controlling Zakuro and protect the city. (Source: ANN)

Despite leading a peaceful life as the princess of a subterraneous colony, teenage Patema longs to escape her cramped industrial confines and experience someplace different. While satiating her curiosity by exploring a region known as the "danger zone," she is startled by a cloaked figure and falls into the darkness of an abyss. Awakening with the sky below her feet and the ground hanging above, Patema finds herself clinging to a fence at the mercy of a seemingly reversed gravity. Although a nearby student named Age is able to rescue her, they are left wondering which of the two is actually upside down.