10,000 years in the future, the world has become a very different place; monsters roam the land freely, and people, although equipped with high tech weapons and cybernetic horses, live a humble life more suited to centuries past. The story focuses on a small hamlet plagued by monster attacks and living under the shadow of rule by Count Magnus Lee, a powerful vampire lord who has ruled the land for thousands of years. When a young girl is bitten by the Count and chosen as his current plaything, she seeks out help of a quiet wandering stranger, D. It so happens that D is one of the world's best vampire hunters, and he takes it upon himself to cut through Magnus Lee's many minions, and put an end to the Count's rule. (Source: AniDB)

Black Bloods and Red Bloods, vampires and humans. Despite their differences, these two races once fought together in a crusade against a formidable foe. A decade later, the vampire war hero Jirou Mochizuki, known as the "Silver Blade," travels with his younger brother Kotarou to the Special Zone—a safe haven where vampires and humans live in harmony. However, their journey is suddenly faced with danger when a conflict erupts between vampire migrants and human forces from the Special Zone. With the rise of a developing conspiracy from an old enemy, Jirou will need the help of his new ally, Mimiko "Compromiser" Katsuragi, as well as the power of his ancient bloodline to protect what he treasures the most.